Author(s): Beth Shapiro
Could extinct species, like mammoths and passenger pigeons, be brought back to life? The science says yes. In How to Clone a Mammoth, Beth Shapiro, evolutionary biologist and pioneer in "ancient DNA" research, walks readers through the astonishing and controversial process of de-extinction. From deciding which species should be restored, to sequencing their genomes, to anticipating how revived populations might be overseen in the wild, Shapiro vividly explores the extraordinary cutting-edge science that is being used--today--to resurrect the past. Journeying to far-flung Siberian locales in search of ice age bones and delving into her own research--as well as those of fellow experts such as Svante Paabo, George Church, and Craig Venter--Shapiro considers de-extinction's practical benefits and ethical challenges. Would de-extinction change the way we live? Is this really cloning? What are the costs and risks? And what is the ultimate goal? Using DNA collected from remains as a genetic blueprint, scientists aim to engineer extinct traits--traits that evolved by natural selection over thousands of years--into living organisms.
But rather than viewing de-extinction as a way to restore one particular species, Shapiro argues that the overarching goal should be the revitalization and stabilization of contemporary ecosystems. For example, elephants with genes modified to express mammoth traits could expand into the Arctic, re-establishing lost productivity to the tundra ecosystem. Looking at the very real and compelling science behind an idea once seen as science fiction, How to Clone a Mammoth demonstrates how de-extinction will redefine conservation's future.
One of Flavorwire's 10 Must-Read Academic Books for 2015 "[Shapiro] goes to great lengths to demystify the art and science of cloning."--Kirkus Reviews "Some of the best conversations I've had in recent months have come about while discussing de-extinction. The concept is simple: should we clone extinct animals, Jurassic Park-style, from found genetic material? How do we do it? What would the impact be on the environment? Shapiro makes it clear that we should have this discussion now because the future of de-extinction is real and coming fast."--Andrew Sturgeon, Flavorwire, from "10 Must-Read Academic Books of 2015" "[A] fascinating book... A great popular science title, and one that makes it clear that a future you may have imagined is already underway."--Library Journal, starred review
Beth Shapiro is associate professor of ecology and evolutionary biology at the University of California, Santa Cruz. Her work has appeared in numerous publications, including Nature and Science, and she was a 2009 recipient of a MacArthur Award. She lives in Santa Cruz.
Prologue ix Chapter 1 Reversing Extinction 1 Chapter 2 Select a Species 17 Chapter 3 Find a Well-Preserved Specimen 51 Chapter 4 Create a Clone 73 Chapter 5 Breed Them Back 99 Chapter 6 Reconstruct the Genome 109 Chapter 7 Reconstruct Part of the Genome 125 Chapter 8 Now Create a Clone 141 Chapter 9 Make More of Them 159 Chapter 10 Set Them Free 175 Chapter 11 Should We? 189 Acknowledgments 209 Notes 211 Index 213