Ed Wintle is an early-40s Manhattanite living the nice, orderly life of an urban single gay man. Tiffany is Ed's "thirteen-going-on-thirty" talented and troubled niece whose single mother is at her wit's end dealing with her daughter. So Ed - the uncle she idolizes, invites Tiffany - the niece he adores, to live with him in New York City. Breakfast with Tiffany chronicles the joys and struggles of their first school year together.